So, the aim of our study was to define the contribution of AGTR1 rs275651 genotypes to the course and outcomes of critical illness, complicated with sepsis. AGTR1 rs275651 AA genotype is associated with unstable angina. The AGTR1 gene encodes angiotensin II receptor type 1, which is involved in cardiovascular diseases. Angiotensin II receptor type 1 (AGTR1) affects the condition of the vessel wall and arteriolar tone. Dysregulation of blood pressure makes a significant contribution during sepsis, especially septic shock. Introduction: International studies demonstrate an annual increase in the frequency and impact of sepsis in intensive care units (ICU). Negovsky’ Research Institute of General Reanimatology, Moscow, Russian Federation Grigoryev Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V. AGTR1 rs275651 AA genotype links with better survival in sepsis patients in ICU A.
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